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Job highlights

Work/Life Balance

Time management

challenging projects

Insurance

Roles & Responsibilities:

  • Read and understand various in vitro ADME protocols.
  • Conduct in vitro stability experiments (liver microsomes, plasma, and other relevant matrices) for new chemical entities.
  • Conduct the following in vitro ADME experiments:
    • logP, logD, pKa measurements
    • CYP induction and inhibition assays
    • Permeability determinations (Caco-2, MDCK, etc.) in relevant cell lines
    • CYP phenotyping in purified enzyme systems
    • Solubility determinations (kinetic, thermodynamic, simulated fluids)
  • Read and understand the bioanalysis sections in the study protocols.
  • LC-MS/MS and HPLC-UV/PDA method development and validation (partial and complete).
  • Develop fit-for-purpose LC-MS/MS methods for routine in vitro and in vivo sample analysis.
  • Extract data from the instrument, conduct bioanalytical QC, and share with stakeholders within the DMPK department.
  • Experience in handling bioanalytical method development for various matrices (plasma, blood, various tissues, urine, faeces, etc.).
  • Develop LC-MS/MS or RF-MS/MS methods for biochemical and cell-based screening of NCEs.
  • Conduct biomarker estimations in various matrices.
  • General LC-MS/MS and HPLC maintenance and troubleshooting.

Application Link

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Oppurtunity For M.Pharm as Research Associate in Jubilant

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