PBPK Scientist Job in India – Pharma Research Role at AstraZeneca

AstraZeneca is a global, science-led biopharmaceutical company focused on discovering, developing, and commercializing prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals. With a strong commitment to innovation, we push the boundaries of science to deliver life-changing medicines to patients worldwide.

Our Clinical Pharmacology & Quantitative Pharmacology (CPQP) team plays a crucial role in drug development by leveraging Model-Informed Drug Development (MIDD) approaches, including PBPK modeling, to optimize clinical trials and regulatory submissions.

Key Responsibilities

As a Senior Scientist in Clinical PBPK Modeling, you will:

• Develop and apply Physiologically-Based Pharmacokinetic (PBPK) models to predict drug-drug interactions (DDIs), pediatric dosing, and special population pharmacokinetics.
• Collaborate with DMPK and Clinical Pharmacology teams to support drug development decisions.
• Validate PBPK models for regulatory submissions (FDA, EMA, etc.) and influence clinical trial designs.
• Stay updated with regulatory guidelines, emerging PBPK science, and industry best practices.
• Communicate findings effectively through internal reports, regulatory documents, and scientific publications.

Essential Qualifications

• PhD, M.Sc., or Pharm.D. in Pharmacology, Pharmaceutical Sciences, or related field.
• 0-4 years of experience in PBPK modeling & simulation (academia or industry).
• Proficiency in PBPK software (SimCYP, GastroPlus, PK-Sim, Phoenix WinNonlin).
• Strong understanding of pharmacokinetics, drug metabolism, and MIDD.
• Experience with regulatory submissions (e.g., DDI reports, pediatric plans).
• Excellent written and verbal communication skills (English).

Desirable Skills

• Experience in early/late-stage drug development.
• Track record of scientific publications in DMPK/Clinical Pharmacology.
• Knowledge of global regulatory expectations for PBPK modeling.

Why Join AstraZeneca?

• Work in a collaborative, science-driven environment with global experts.
• Opportunity to contribute to cutting-edge drug development and regulatory strategies.
• Flexible hybrid work model (minimum 3 days/week in-office).
• Career growth in a company that values innovation, diversity, and lifelong learning.

How to Apply

Application Link